Hierarchical Two-Dimensional Layered Double Hydroxide Coated Polydopamine Nanocarriers for Combined Chemodynamic and Photothermal Tumor Therapy
نویسندگان
چکیده
The combination of chemodynamic therapy (CDT) and photothermal (PTT) has proven to be successful in combating the challenges associated with cancer therapy. A these therapies can maximize benefits each therapeutic modality through endogenous reduction-oxidation (redox) reaction external laser power induction. In current work, we have designed a copper-aluminum layered double hydroxide (CuAl-LDH) loaded doxorubicin (DOX) by co-precipitation method; surface was coated polydopamine (PDA). synthesized CuAl-LDH@DOX@PDA nanocarrier (NC) served as Fenton-like catalyst properties. It is well known that metal ion incorporated NCs induce intracellular depletion reduced glutathione (GSH) levels along reduction Cu2+ Cu+. Cu+ ions turn react DOX leading generation hydrogen peroxide (H2O2) molecules produce highly toxic hydroxyl radicals (•OH) reaction. enhanced absorption CuAl@DOX@PDA at 810 nm, greatly improved efficiency comparison bare CuAl-LDH CuAl-LDH@DOX. vitro studies revealed tremendous CDT/PTT efficacy suppressing A549 cells. Furthermore, reactive oxygen species (ROS) assays various ROS cascade biomolecules support our findings efficient destruction cells synergistic
منابع مشابه
Layered Double Hydroxide-Based Nanocarriers for Drug Delivery
Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materi...
متن کاملPolydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver ...
متن کاملPolymer Coated CaAl-Layered Double Hydroxide Nanomaterials for Potential Calcium Supplement
We have successfully prepared layered double hydroxide (LDH) nanomaterials containing calcium and aluminum ions in the framework (CaAl-LDH). The surface of CaAl-LDH was coated with enteric polymer, Eudragit®L 100 in order to protect nanomaterials from fast dissolution under gastric condition of pH 1.2. The X-ray diffraction patterns, Fourier transform infrared spectroscopy, scanning electron an...
متن کاملAmine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery
متن کامل
Hollow nanoshell of layered double hydroxide.
Hollow nanoshells of layered double hydroxide (LDH) have been fabricated using exfoliated LDH nanosheets as a shell building block and polystyrene beads as a sacrificial template.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Coatings
سال: 2021
ISSN: ['2079-6412']
DOI: https://doi.org/10.3390/coatings11081008